Augmentin (amoxicillin-clavulanate) Indication Anti-infectives

Breastfeeding Both substances are excreted into breast milk (nothing is known of the effects of clavulanic acid on the breast-fed infant). By continuing to browse the site you are agreeing to our policy on the use of cookies. Clavulanic acid is extensively metabolized in man and eliminated in urine and faeces, and as carbon dioxide in expired air. Therapy can be started parenterally according the SPC of the IV formulation and continued with an oral preparation. Amoxicillin/clavulanic acid should be used with caution in patients with evidence of hepatic impairment (see sections.2,.3 and.8). Amoxicillin/clavulanic acid should only be used during breast-feeding after benefit/risk assessment by the physician in charge. Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of any antibiotics.

Zusammenfassung DER merkmale DES arzneimittels

Commonly susceptible species Aerobic Gram-positive micro-organisms Enterococcus faecalis Gardnerella vaginalis Staphylococcus aureus (methicillin-susceptible) Coagulase-negative staphylococci (methicillin-susceptible) Streptococcus agalactiae Streptococcus pneumoniae 1 Streptococcus pyogenes and other beta-haemolytic streptococci Streptococcus viridans group Aerobic Gram-negative micro-organisms Capnocytophaga spp. 7 If any hypersensitivity dermatitis reaction occurs, treatment should be discontinued (see section.4). However, close clinical monitoring should be performed during the combination and shortly after antibiotic treatment. Trace quantities of clavulanic acid can also be detected in breast milk (see section.6). Mean ( SD) pharmacokinetic parameters Active substance(s) administered Dose Cmax Tmax * AUC (0-24h) T 1/2 (mg) (g/ml) (h) (g.h/ml) (h) Amoxicillin AMX/CA 500/125 mg 500.19.26.5 (1.0-2.5).5.87.15.20 Clavulanic acid AMX/CA 500. Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed. Do not store above 25C. The presence of clavulanic acid in Augmentin may cause a non-specific binding of IgG and albumin by red cell membranes leading to a false positive Coombs test. In order to restore circulating drug levels, 15 mg/3.75 mg per kg should be administered after haemodialysis. Augmentin should be administered with a meal to minimise potential gastrointestinal intolerance. 5 Breakpoint values in the table are based on benzylpenicillin breakpoints. Copyright Cerner Multum, Inc. Convulsions may occur in patients with impaired renal function or in those receiving high doses. Very common (1/10) Common (1/100 to 1/10) Uncommon (1/1,000 to 1/100) Rare (1/10,000 to 1/1,000) Very rare ( 1/10,000) Not known (cannot be estimated from the available data) Infections and infestations Mucocutaneous candidosis Common Overgrowth of non-susceptible organisms Not known Blood. Eikenella corrodens Haemophilus influenzae 2 Moraxella catarrhalis Pasteurella multocida Anaerobic micro-organisms Bacteroides fragilis Fusobacterium nucleatum Prevotella spp.

Augmentin 250 mg/125 mg filmtabletta

Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes. Renal impairment The total serum clearance of amoxicillin/clavulanic acid decreases proportionately with decreasing renal function. Clavulanic acid is a beta-lactam structurally related to penicillins. Qualitative and quantitative composition, each film-coated tablet contains amoxicillin trihydrate equivalent to 500 mg amoxicillin and potassium clavulanate equivalent to 125 mg of clavulanic acid. Convulsions may occur in patients with impaired renal function or in those receiving high doses (see section.8). Legionella pneumophila Morganella morganii Providencia spp. Therefore, positive test results in patients receiving amoxicillin/clavulanic acid should be interpreted cautiously and confirmed by other diagnostic methods. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. Aluminium PVC/PVdC blister enclosed within an aluminium laminate pouch containing a desiccant sachet, referred to as a desiccated pouch (DPP) containing 14, 20 or 21 tablets. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Go to, top, close, augmentin is an antibiotic agent with a notably broad spectrum of activity against the commonly occurring bacterial pathogens in general practice and hospital.

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