Die Top 10 der Studentenmedikamente - vice

TMP-SMX or, tMP-SMZ ). Imodium (loperamide) for a couple of days, just to decrease the frequency of diarrhea while her body is getting rid of the problem. Such drugs are also prescribed to treat congestive heart failure (CHF heart disease and kidney disease. They get warnings like that dozens of times a day. This is a crazy world where one plus one equals three, where down may very well be up and surely pigs have wings. Their Conclusion: We found that use of co-trimoxazole was associated with an increased risk of sudden death in older patients taking angiotensin converting enzyme inhibitors or angiotensin receptor blockers. Sudden death in these patients is likely to be misattributed to underlying cardiovascular disease, rather than hyperkalemia. RAS (Renin-Angiotensin System) Inhibitors (aka ARBs and ACEi These are among the most popular blood pressure drugs in the pharmacy. In the 1970s there were no computers for physicians or pharmacists to use to check for dangerous interactions and there were few references available to check out a possible problem. The interaction can lead to dangerously high levels of potassium (hyperkalemia) in the body, which in turn can trigger fatal heart rhythm abnormalities. Sadly, there is not adequate awareness about the deadly consequences of this drug interaction. Now, we have computers as close as our smart phones.

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Experts estimate that over 250 million prescriptions are written for angiotensin receptor blockers (ARBs) and ACE (angiotensin converting enzyme) inhibitors. Drinking or eating just little bits, is helpful (not over-eating nor over-drinking). More recent research has found that people with poor kidney function are particularly likely to suffer from this interaction ( Internal Medicine, March 1, 2016 ). In other words, an awful lot of people are vulnerable to this potentially deadly drug combination. The Scary Story Behind this Deadly Drug Discovery: Canadian researchers have been concerned about the combination of the antibiotic co-trimoxazole with ARBs or aceis for years. They noted then that: These findings support the notion of a potentially life-threatening drug interaction between trimethoprim and inhibitors of the renin-angiotensin aldosterone system. Bactrim and, septra were the original brand names for this drug. Quinapril accupril ramipril altace aRBs (Angiotensin Receptor Blockers candesartan atacand irbesartan avapro losartan (. It is estimated that roughly 20 million prescriptions are filled for this drug each year. Selected from data included with permission and copyrighted by First Databank, Inc. A hyperkalemic crisis can come on so suddenly that even if a conscientious doctor were monitoring serum potassium levels every few months that might not be frequently enough to catch a problem in time. Cozaar ) Olmesartan ( Benicar ) Telmisartan ( Micardis ) Valsartan ( Diovan ) These drugs are also included in many combination products. We speculate that this association reflects sudden death from co-trimoxazole induced hyperkalemia in a vulnerable group of patients. This combination antibiotic is prescribed for urinary tract, respiratory, digestive and skin infections, to name just a few of its many applications. They tracked 100,000 people who had received a prescription for one of these blood pressure medications.

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Did you also note that the authors said millions of patients receive this antibiotic in combination with ARBs or ACE inhibitors? The cause of death will likely be assumed to be of natural causes such as a heart attack. Conditions OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. If people you love take multiple medications, this book might save their lives. It goes by many names. Learn More: If this example has you concerned, you may want to read more details in our chapter Drug Interactions Can Be Deadly. The trouble is, physicians and pharmacists often ignore and override drug interaction alerts, especially those they deem relatively unimportant. They looked for cases of sudden death and discovered that patients who had also received co-trimoxazole were significantly more likely to have died within 14 days than those who received the penicillin-type antibiotic amoxicillin. That means it is likely to be ignored by many health professionals. The other seemed even less concerned. The Canadian researchers reported that many of the patients they were tracking died suddenly within one to two weeks of starting this combination. The laws of nature no longer hold true. Automated systems check on interactions before a doctor can finalize a prescription and before a pharmacist can dispense. Those who got the combo were almost seven times more likely to be hospitalized for problems due to high potassium compared to people taking different antibiotics ( Archives of Internal Medicine, June 28, 2010 ).

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