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The every 12 hour regimen is recommended as it is associated with significantly less diarrhea see Clinical Studies (14.2). Prepare a suspension at time of dispensing as follows: Tap bottle until all the powder flows freely. Add remainder of the water and again shake vigorously. Hemodialysis patients should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection. The 200 mg/5 mL suspension or the 400 mg/5 mL suspension may be used in place of the 875-mg tablet. The 250-mg tablet of augmentin should not be used until the child weighs at least 40 kg, due to the different amoxicillin to clavulanic acid ratios in the 250-mg tablet of augmentin (250/125) versus the 250-mg chewable tablet of augmentin (250/62.5). For more severe infections and infections of the respiratory tract, the dose should be one 875-mg tablet of augmentin every 12 hours or one 500-mg tablet of augmentin every 8 hours. Patients Aged 12 weeks (3 months) and Older: See dosing regimens provided in Table. See Warnings and Precautions (5.6). Two 250-mg tablets of augmentin should not be substituted for one 500-mg tablet of augmentin. Since both the 250-mg and 500-mg tablets of augmentin contain the same amount of clavulanic acid (125 mg, as the potassium salt two 250-mg tablets are not equivalent to one 500-mg tablet of augmentin. Table 2: Amount of Water for Mixing Oral Suspension. Adults, the usual adult dose is one 500-mg tablet of augmentin every 12 hours or one 250-mg tablet of augmentin every 8 hours. Otitis mediab, sinusitis, lower respiratory tract infections, and more severe infections 45 mg/kg/day every 12 hours 40 mg/kg/day every 8 hours, less severe infections 25 mg/kg/day every 12 hours 20 mg/kg/day every 8 hours a Each strength of suspension. To minimize the potential for gastrointestinal intolerance, augmentin should be taken at the start of a meal.
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Patients with a glomerular filtration rate less than 10 mL/min should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis. Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp. Table 1: Dosing in Patients Aged 12 weeks (3 months) and Older. Patients with Renal Impairment, patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe. Patients with a glomerular filtration rate of 10 to 30 mL/min should receive 500 mg or 250 mg every 12 hours, depending on the severity of the infection.
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The 250-mg tablet of augmentin and the 250-mg chewable tablet should not be substituted for each other, as they are not interchangeable. However, the every 12 hour suspension (200 mg/5 mL and 400 mg/5 mL) and chewable tablets (200 mg and 400 mg) contain aspartame and should not be used by phenylketonurics. Renal impairment patients with a glomerular filtration rate of 30 mL/min should not receive the 875mg dose.